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pentobarbital will reduce the level or impact of parecoxib by influencing hepatic enzyme CYP2C9/10 metabolism. Use Caution/Observe.pentobarbital will reduce the extent or influence of brexpiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Carefully. Double brexpiprazole dose in excess of one-two months